Team 23 : Hematopoietic development and leukemia: diseases and cell therapy

The work carried out in the team addresses two fundamental aspects of hematology: understanding the mechanisms of the development of acute myeloid leukemia (AML) and the study of hematopoiesis and erythropoiesis from the perspective of transfusion and cell therapy. Three groups are distributed along these two axes while interacting closely. The first group, "Genetics of AML", led by Hélène Lapillonne and François Delhommeau, is studying the genetic lesions that cause AML in adults and children. The program includes the deciphering of the clonal architecture of AML, with particular focus on certain AML predisposition syndromes (Shwachman-Diamond disease or GATA2 syndrome), AML with TP53 mutations, transformations of myeloproliferative syndromes, and genomic tools for personalized follow-up of residual disease or detection of age-related clonal hematopoiesis. The second group, "Stroma and Stem Cells", under the responsibility of Pierre Hirsch, is studying the link between the medullary microenvironment, the development of clonal hematopoiesis and AML, and their clonal architecture. The work includes the study of the dialogue between mesenchymal cells and pre-leukemic and leukemic cells, the analysis of the physiological and pathological composition of medullary plasma in the context of AML, and the investigation of the particular role of variations in certain chemokines and hematopoietic growth factors in the development of AML. The third group, "Blood sources and erythropoiesis", led by Yael Zermati and Laurence Harmand-Guyonneau, is dedicated to the study of physiological and pathological erythropoiesis, the ex vivo production of erythrocytes, and the production of functional hematopoietic stem cells from induced pluripotent cells (IPS), the latter two topics being supported by the Etablissement Français du Sang.   Website: https://www.crsa.fr/equipe-francois-delhommeau.html Affiliations: UMR_S UPMC/Inserm 938, centre de recherches Saint-Antoine Contact: francois.delhommeau@aphp.fr

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