Cancers avec instabilité des microsatellites (MSI)
Coordonné par le Pr. Alex Duval
Les cancers avec instabilité des séquences répétées microsatellites de l’ADN (MSI) constituent une famille de tumeurs fréquentes, associées à de nombreuses localisations (côlon, estomac, endomètre, pancréas, prostate, poumon, sein, ovaire, cerveau,…). Les principaux objectifs de ce programme, dédiés aux cancers MSI de toutes localisations, sont :
- De comprendre les processus qui sous-tendent l’initiation et la progression tumorale MSI et façonnent le microenvironnement de ces cancers.
- De développer de nouveaux outils diagnostiques et schémas thérapeutiques adaptés à leur prise en charge moderne par une médecine de précision en pleine émergence (immunothérapie, inhibiteurs des checkpoints immunitaires).
Synthèse grand public et actualités
🎞 Vidéo : au coeur de la tumeur MSI, mieux connaître pour mieux combattre
Les tumeurs MSI (pour Instabilité des MicroSatellites), sont une catégorie de tumeurs qui possèdent des altérations génomiques dûes à un […]
ASCO 2020 – Session plénière – Pr Thierry André
Congrès Annuel de l’ASCO – Session plénière – Pr Thierry André Le congrès de l’American Society of Clinical Oncology (ASCO) […]
Pembrolizumab dans le cancer colorectal de stade IV MSI-H – KEYNOTE-164 (NCT02460198)
Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164 Le DT, Kim TW, Van […]
Traitements des cancers MSI gastro-intestinaux par immuno-oncologie
How to Improve the Results With IO Agents in MSI GI Cancer? https://oncologypro.esmo.org/content/download/231632/3918938/version/1/file/WORLDGI2019_76_andre.pdf
[ESMO 2019] L’efficacité des inhibiteurs de PD-1 confirmée dans le traitement des tumeurs « MSI »
L’analyse poolée de deux études KEYNOTE-164 et KEYNOTE-168, à laquelle le Pr Thierry André, chef du service d’oncologie digestive de […]
Publications
Articles originaux
2022
- Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice. Noel et al. Cell Mol Life Sci. 2022 Jun.
- Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability-High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study. André et al. J Clin Oncol. 2022 Aug.
- Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142. André et al. Ann Oncol. 2022 Jun.
2021
- Performance of Next-Generation Sequencing for the Detection of Microsatellite Instability in Colorectal Cancer With Deficient DNA Mismatch Repair. Ratovomanana et al. Gastroenterology. 2021 Sep.
- Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer. Cohen et al. J Immunother Cancer. 2021 Feb.
- Microsatellite Instability in Patients With Stage III Colon Cancer Receiving Fluoropyrimidine With or Without Oxaliplatin: An ACCENT Pooled Analysis of 12 Adjuvant Trials. Cohen et al. J Clin Oncol. 2021 Feb.
- Pseudoprogression in patients treated with immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer. Colle et al. Eur J Cancer. 2021 Feb.
2020
- KEYNOTE-177 Investigators. Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer. André et al. N Engl J Med. 2020 Dec.
- Overcoming the challenges associated with universal screening for Lynch syndrome in colorectal and endometrial cancer. Benusiglio et al. Genet Med. 2020 Aug.
- Mechanisms and therapeutic implications of hypermutation in gliomas. Touat et al. Nature. 2020 Apr.
- Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France PRODIGE-GERCOR cohort study. Pagès et al. Ann Oncol. 2020 Jul.
- Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164. Le et al. J Clin Oncol. 2020 Jan.
- RECIST and iRECIST criteria for the evaluation of nivolumab plus ipilimumab in patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: the GERCOR NIPICOL phase II study. Cohen et al. J Immunother Cancer. 2020 Nov.
2019
- Low temperature isothermal amplification of microsatellites drastically reduces stutter artifact formation and improves microsatellite instability detection in cancer. Daunay et al. Nucleic Acids Res. 2019 Dec.
- Methylation Tolerance-Based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome. Bouvet et al. Gastroenterology. 2019 Aug.
- Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer-Beyond the Misdiagnosis-In Reply. Cohen et al. JAMA Oncol. 2019 May.
- Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies. Taieb et al. Ann Oncol. 2019 Sep.
- Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status. Cohen et al. JAMA Oncol. 2019 Apr.
- MSI/MMR-deficient tumor diagnosis: Which standard for screening and for diagnosis? Diagnostic modalities for the colon and other sites: Differences between tumors. Svrcek et al. Bull Cancer. 2019 Feb.
- Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status. Cohen et al. JAMA Oncol. 2019 Jan.
2018
- Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability. Bokhari et al. Oncogenesis. 2018 Sep.
- Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability. Jonchere et al. Cell Mol Gastroenterol Hepatol. 2018 Jun.
- Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas. Lupinacci et al. Gastroenterology. 2018 Mar.
- Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer. Overman et al. J Clin Oncol. 2018 Mar.
- The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors. Marisa et al. JNCI 2018 Jan.
Revues
2022
- The Role of Immunohistochemistry Markers in Endometrial Cancer with Mismatch Repair Deficiency: A Systematic Review. Favier et al. Cancers (Basel). 2022 Aug.
2021
- Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency. Cohen et al. Cancers (Basel). 2021 Mar.
2019
- Microsatellite instability and cancer: from genomic instability to personalized medicine. Collura et al. Med Sci (Paris). 2019 Jun-Jul.