{"id":1782,"date":"2019-10-24T11:52:16","date_gmt":"2019-10-24T09:52:16","guid":{"rendered":"https:\/\/curamus-cancer.fr\/esmo-2019-lefficacite-des-inhibiteurs-de-pd-1-confirmee-dans-le-traitement-des-tumeurs-msi\/"},"modified":"2020-05-10T13:37:44","modified_gmt":"2020-05-10T11:37:44","slug":"esmo-2019-efficacy-of-pd-1-inhibitors-confirmed-in-the-treatment-of-msi-tumours","status":"publish","type":"post","link":"https:\/\/curamus-cancer.fr\/en\/esmo-2019-efficacy-of-pd-1-inhibitors-confirmed-in-the-treatment-of-msi-tumours\/","title":{"rendered":"[ESMO 2019] Efficacy of PD-1 Inhibitors Confirmed in the Treatment of &#8220;MSI&#8221; Tumours"},"content":{"rendered":"<p><strong>The pooled analysis of two studies, KEYNOTE-164 and KEYNOTE-168, in which Pr Thierry Andr\u00e9, Head of the Digestive Oncology Department at the Saint-Antoine AP-HP Hospital, participated, confirms the exceptional efficacy of pembrolizumab (anti-PD1 antibodies) in the treatment of unstable micro satellite cancers (MSI), rare colorectal cancers that occur either in a hereditary context of Lynch syndrome or spontaneously without any particular environment with an incidence that increases with age. This particular form, characterized by abnormalities in DNA repair, promotes the formation and development of cancer cells. To date, MSI status is the best predictor of response to PD-1 inhibitors. These data will be presented orally at the ESMO congress on Monday, September 30, 2019.\u00a0<\/strong><\/p>\n<p>More information : <a href=\"https:\/\/www.aphp.fr\/contenu\/esmo-2019-lefficacite-des-inhibiteurs-de-pd-1-confirmee-dans-le-traitement-des-tumeurs-msi\">https:\/\/www.aphp.fr\/contenu\/esmo-2019-lefficacite-des-inhibiteurs-de-pd-1-confirmee-dans-le-traitement-des-tumeurs-msi<\/a><\/p>\n<p><strong><em><u>Source:<\/u><\/em><\/strong><\/p>\n<p><strong><em>Pembrolizumab in microsatellite instability high cancers: updated analysis of the phase 2 KEYNOTE-164 and KEYNOTE-158 studies. 1174O &#8211; Lecture time: 10:15 &#8211; 10:30<\/em><\/strong><\/p>\n<p>L. Diaz, D. Le, M. Maio, P. Ascierto, R. Geva, D. Motola-Kuba, T. Andr\u00e9, E. Van Cutsem, M. Gottfried, E. Elez, J.-P. Delord, D. J\u00e4ger, T.W. Kim, R. Guimbaud, T. Yoshino, M. Chen, K. Norwood, P. Marinello, A. Marabelle.<\/p>\n<p>&nbsp;<\/p>\n<p><iframe title=\"How to Improve the Results With IO Agents in MSI GI Cancer\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/LR7MB6a70uc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The pooled analysis of two studies, KEYNOTE-164 and KEYNOTE-168, in which Pr Thierry Andr\u00e9, Head of the Digestive Oncology Department [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":1784,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[23],"tags":[],"class_list":["post-1782","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-msi-vulgarise-en-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>[ESMO 2019] Efficacy of PD-1 Inhibitors Confirmed in the Treatment of &quot;MSI&quot; Tumours - Siric Cancer - Curamus - Site de Recherche Int\u00e9gr\u00e9e sur le Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/curamus-cancer.fr\/en\/esmo-2019-efficacy-of-pd-1-inhibitors-confirmed-in-the-treatment-of-msi-tumours\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[ESMO 2019] Efficacy of PD-1 Inhibitors Confirmed in the Treatment of &quot;MSI&quot; Tumours - Siric Cancer - Curamus - Site de Recherche Int\u00e9gr\u00e9e sur le Cancer\" \/>\n<meta property=\"og:description\" content=\"The pooled analysis of two studies, KEYNOTE-164 and KEYNOTE-168, in which Pr Thierry Andr\u00e9, Head of the Digestive Oncology Department [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/curamus-cancer.fr\/en\/esmo-2019-efficacy-of-pd-1-inhibitors-confirmed-in-the-treatment-of-msi-tumours\/\" \/>\n<meta property=\"og:site_name\" content=\"Siric Cancer - Curamus - Site de Recherche Int\u00e9gr\u00e9e sur le Cancer\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/cancercuramus\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-10-24T09:52:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-10T11:37:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/curamus-cancer.fr\/wp-content\/uploads\/2019\/10\/ESMO-2019-Banner-e1571912385104.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"679\" \/>\n\t<meta property=\"og:image:height\" content=\"367\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sarah L\u00e9vesque\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sarah L\u00e9vesque\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/curamus-cancer.fr\\\/en\\\/esmo-2019-efficacy-of-pd-1-inhibitors-confirmed-in-the-treatment-of-msi-tumours\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/curamus-cancer.fr\\\/en\\\/esmo-2019-efficacy-of-pd-1-inhibitors-confirmed-in-the-treatment-of-msi-tumours\\\/\"},\"author\":{\"name\":\"Sarah L\u00e9vesque\",\"@id\":\"https:\\\/\\\/curamus-cancer.fr\\\/en\\\/#\\\/schema\\\/person\\\/46844c50d4f01ec82bf18429533914ba\"},\"headline\":\"[ESMO 2019] Efficacy of PD-1 Inhibitors Confirmed in the Treatment of &#8220;MSI&#8221; 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